SAMe (S-Adenosylmethionine)SAMe with improved stability to promote healthy balance of humors and comfort of osteoarthritic joints SAMe (S Adenosylmethionine) is a metabolite present in all living cells. It is a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids and proteins. Methyl groups act as a signal in the body, regulating gene expression and